Thiolutin, RNA polymerase inhibitor

• Catalog number
  SIH-375-1MG
• Price
  Please ask
• Size
  1 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  87-11-6
• Description
  RNA polymerase inhibitor
• Molecular weight
  228,3 g/mol
• Primary research fields
  Cell Signaling, Epigenetics
• Other name
  N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C8H8N2O2S2
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (TLC); NMR (Conforms)
• Soluble in
  May be dissolved in DMSO (15 mg/ml)
• Physical appearance
  Yellow powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Danger. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H300 – Fatal if swallowed H330 – Fatal if inhaled Precautionary Phrases: P260 – Do not breathe dust/fume/gas/mist/vapours/spray P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P405 – Store locked up
• PubChem number
  6870
• Scientific context
  Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at more.
• Bibliography
  1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.
• Release date
  4-Apr-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Thiolutin (SIH-375), a HSP27 perturbing agent. CAS #: 87-11-6. Molecular Formula: C8H8N2O2S2. Molecular Weight: 228.3 g/mol. Chemical structure of Thiolutin, a HSP27 perturbing agent (SIH-375). CAS # 87-11-6. Molecular Formula: C8H8N2O2S2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.001
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Thiolutin   RNA   polymerase   inhibitor  
• Short name
  Thiolutin, RNA polymerase inhibitor
• Technique
  RNAs are to store at -70 C
• Alternative name
  Thiolutin, RNA polymerizing enzyme suppressor

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