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Stock availabilitIn Stock
In Stock
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CAS number
301836-41-9
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Description
ALK4,5 and 7 kinase inhibitor
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Molecular weight
384,4 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C22H16N4O3
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble to 10 mM in ethanol and to 100 mM in DMSO
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
4521392
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Scientific context
SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor, activin receptor-like kinases. It has been shown to inhibit ALK4, 5, and 7.
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Bibliography
1. Laping N.J., et al. (2002) Mol. Pharm. 62(1): 58–64.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of SB431542 (SIH-511), a ALK4,5 and 7 kinase inhibitor. CAS #: 301836-41-9. Molecular Formula: C22H16N4O3. Molecular Weight: 384.4 g/mol. Chemical structure of SB431542, a ALK4,5 and 7 kinase inhibitor (SIH-511). CAS # 301836-41-9. Molecular Formula: C22H16N4O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
