Pyr3, TRPC3 Channel blocker

• Catalog number
  SIH-306-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  1160514-60-2
• Description
  TRPC3 Channel blocker
• Molecular weight
  456,63 g/mol
• Primary research fields
  Neuroscience, Ion Channels, Transient Receptor Potential Channels
• Other name
  Ethyl 1-{4-[(2,3,3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C16H11Cl3F3N3O3
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  56964346
• Scientific context
  Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
• Bibliography
  1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol. Chemical structure of Pyr3, a TRPC3 Channel blocker (SIH-306). CAS # 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  Pyr3   TRPC3   Channel   blocker  
• Gene symbol
  TRPC3
• Short name
  Pyr3, TRPC3 Channel blocker
• Alternative name
  Pyr3, TRPC3 Channel blocker

Gene info

• Identity
  HGNC:12335
• Gene
  TRPC3
• Long gene name
  transient receptor potential cation channel subfamily C member 3
• Synonyms gene name
  • transient receptor potential cation channel, subfamily C, member 3
• GenBank acession
  • Y13758
• Locus
  4q27
• Discovery year
  1995-09-01
• Entrez gene record
  7222
• Pubmed identfication
  • 8646775
  • 16382100
• RefSeq identity
  • NM_003305
• Classification
  • Transient receptor potential cation channels
• VEGA ID
  OTTHUMG00000133069

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