PP1, Src kinase inhibitor
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Catalog numberSIH-469-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS number172889-26-8
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DescriptionSrc kinase inhibitor
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Molecular weight281,4 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC16H19N5
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OriginSynthetic
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Purity pourcentage≥ 98% (TLC)
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Soluble inSoluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
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Physical appearanceTan solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number1400
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Scientific contextPP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
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Bibliography1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of PP1 (SIH-469), a Src family kinase inhibitor. CAS #: 172889-26-8. Molecular Formula: C16H19N5. Molecular Weight: 281.4 g/mol. Chemical structure of PP1, a Src family kinase inhibitor (SIH-469). CAS # 172889-26-8. Molecular Formula: C16H19N5.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolNPY4R, PPA1
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Short namePP1, Src kinase inhibitor
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Alternative namePP1, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) phosphorylation catalyst suppressor
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Alternative to gene targetv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), ASV and c-SRC and p60-Src and SRC1, SRC and IDBG-74081 and ENSG00000197122 and 6714, transferase activity, nuclei, Src and IDBG-211273 and ENSMUSG00000027646 and 20779, BT.61976 and IDBG-642561 and ENSBTAG00000008938 and 535742
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Gene info
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Identity
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Gene
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Long gene nameneuropeptide Y receptor Y4
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Synonyms gene
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Synonyms gene name
- pancreatic polypeptide receptor 1
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Synonyms
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Locus
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Discovery year1996-04-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Neuropeptide Y receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinorganic pyrophosphatase 1
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Synonyms gene
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Synonyms gene name
- pyrophosphatase (inorganic)
- pyrophosphatase (inorganic) 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID