PMA, PKC kinase activator

• Catalog number
  SIH-508-1MG
• Price
  Please ask
• Size
  1 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  16561-29-8
• Description
  PKC kinase activator
• Molecular weight
  616,8 g/mol
• Primary research fields
  Cell Signaling
• Other name
  Phorbol 12-myristate 13-acetate
• Product category
  Small Molecules
• Product type
  Activator
• Chemical formula
  C36H58O8
• Origin
  Synthetic
• Purity pourcentage
  ≥99% (TLC)
• Soluble in
  Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers
• Physical appearance
  Colorless amorphous film or foam
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. Precautionary statements: P264 Wash skin thoroughly after handling. P280 Wear protective gloves. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse.
• PubChem number
  27924
• Scientific context
  PMA (Phorbol 12-myristate 13-acetate) is a phorbol ester. It is used experimentally as a reversible protein kinase C (PKC) activator. It has been shown to be a potent tumor promoter.
• Bibliography
  1. Murphy T. V., Prountzos C., Kotsonis P., Iannazzo L., & Majewski H. (1999). Euro.J. Pharm. 381(1): 77–84. 2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847–7851.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol. Chemical structure of PMA, a PKC kinase activator (SIH-508). CAS # 16561-29-8. Molecular Formula: C36H58O8.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.001
• Other related products

• Gene target
  PMA   PKC   kinase   activator  
• Gene symbol
  PRKCH, PRKD1, PRRT2, PRKDC
• Short name
  PMA, PKC kinase activator
• Alternative name
  PMA, PKC phosphorylation catalyst activator

Gene info

• Identity
  HGNC:9403
• Gene
  PRKCH
• Long gene name
  protein kinase C eta
• Synonyms gene
  • PRKCL
• Synonyms gene name
  • protein kinase C, eta
• Synonyms
  • PKC-L
  • PKCL
• GenBank acession
  • M55284
• Locus
  14q23.1
• Discovery year
  1992-06-26
• Entrez gene record
  5583
• Pubmed identfication
  • 1986216
  • 1545821
• RefSeq identity
  • NM_006255
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
• VEGA ID
  OTTHUMG00000152341

Gene info

• Identity
  HGNC:9407
• Gene
  PRKD1
• Long gene name
  protein kinase D1
• Synonyms gene
  • PRKCM
• Synonyms gene name
  • protein kinase C, mu
• Synonyms
  • PKCM
  • PKD
  • PKC-mu
• Locus
  14q12
• Discovery year
  1994-05-16
• Entrez gene record
  5587
• Pubmed identfication
  • 8119958
  • 10965134
• RefSeq identity
  • NM_002742
• Classification
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000140203

Gene info

• Identity
  HGNC:30500
• Gene
  PRRT2
• Long gene name
  proline rich transmembrane protein 2
• Synonyms gene
  • ICCA
  • DYT10
• Synonyms gene name
  • infantile convulsions and paroxysmal choreoathetosis
  • dystonia 10
  • proline-rich transmembrane protein 2
• Synonyms
  • FLJ25513
  • DKFZp547J199
  • IFITMD1
  • FICCA
  • DSPB3
  • PKC
  • EKD1
• Synonyms name
  • interferon induced transmembrane protein domain containing 1
  • dispanin subfamily B member 3
• GenBank acession
  • BC011405
• Locus
  16p11.2
• Discovery year
  2005-11-25
• Entrez gene record
  112476
• Pubmed identfication
  • 22101681
  • 22243967
  • 29346777
• RefSeq identity
  • NM_145239
• Classification
  • interferon induced transmembrane protein domain containing
• VEGA ID
  OTTHUMG00000177142

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

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