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Stock availabilitIn Stock
In Stock
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CAS number
444731-52-6
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Description
Tyrosine kinase inhibitor
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Molecular weight
437,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C21H23N7O2S
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO, not in water
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Physical appearance
White solid powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
10113978
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Scientific context
Pazopanib is a multi-tyrosine kinase inhibitor. It was approved by the US Food and Drug Administration in 2009. Pazopanib exerted antitumor effects through the inhibition of HGF/c-MET signaling.
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Bibliography
1. Outani H., et al. (2014) BMC Cancer. 14: 455. 2. Pick A.M., & Nystrom K.K. (2012) Clin. Ther. 34(3): 511–520.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Pazopanib (SIH-506), a Multi target receptor tyrosine kinase inhibitor. CAS #: 44473-52-6. Molecular Formula: C21H23N7O2S. Molecular Weight: 437.5 g/mol. Chemical structure of Pazopanib, a Multi target receptor tyrosine kinase inhibitor (SIH-506). CAS # 44473-52-6. Molecular Formula: C21H23N7O2S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.