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Stock availabilitIn Stock
In Stock
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CAS number
1285702-20-6
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Description
Clk4 kinase inhibitor
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Molecular weight
335,4 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
ml-167, 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol, CID 44968231, NCGC00188654
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C19H17N3O3
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble in DMSO 10 mg/ml, clear
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Physical appearance
Off-white to gray to brown
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 4), H302 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P330 Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
51347463
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Scientific context
ml167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4). The Cdc2-like kinases are involved in regulation of gene splicing.
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Bibliography
1. Rosenthal A.S., et al. (2010). In Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US).
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of ML167 (SIH-505), a Clk4 kinase inhibitor. CAS #: 1285702-20-6. Molecular Formula: C19H17N3O3. Molecular Weight: 335.4 g/mol. Chemical structure of ML167, a Clk4 kinase inhibitor (SIH-505). CAS # 1285702-20-6. Molecular Formula: C19H17N3O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
