Mitomycin C, DNA synthesis inhibitor
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Catalog numberSIH-246-10MG
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PricePlease ask
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Size10 mg
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Stock availabilitIn StockIn Stock
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CAS number50-07-7
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DescriptionDNA synthesis inhibitor
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Molecular weight334,33 g/mol
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Primary research fieldsCancer, Apoptosis
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Other name[(1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC15H18N4O5
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble to 100 mM in DMSO, 5 mM water, and to 5 mM Ethanol
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Physical appearanceDark Purple Crystalline Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Very toxic. May be fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed R46 - May cause heritable genetic damage R61 - May cause harm to the unborn child R62 - Possible risk of impaired fertility Hazard Phrases: H302-H351 Precautionary Phrases: P281
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PubChem number5746
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Scientific contextThe mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5’-CpG-3’ (1).
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Bibliography1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.
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Release date8-Apr-2011
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Mitomycin C (SIH-246), a DNA crosslinking and damaging agent. CAS #: 50-07-7. Molecular Formula: C15H18N4O5. Molecular Weight: 334.33 g/mol. Chemical structure of Mitomycin C, a DNA crosslinking and damaging agent (SIH-246). CAS # 50-07-7. Molecular Formula: C15H18N4O5.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.01
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPRKDC, HLA-DOA
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Short nameMitomycin C, DNA synthesis inhibitor
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Techniquedna
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Alternative nameMitomycin C, Desoxyribonucleic acid synthesis suppressor
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Gene info
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Identity
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Gene
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Long gene nameprotein kinase, DNA-activated, catalytic subunit
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Synonyms gene
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Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DO alpha
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases