Lysophosphatidic Acid, Sodium Salt, Autophagy inhibitor

• Catalog number
  SIH-403-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  22556-62-3
• Description
  Autophagy inhibitor
• Molecular weight
  458,5 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  Oleoyl-lysophosphatidic acid sodium salt
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C21H41O7P*Na
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
• Physical appearance
  White powder.
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  5311263
• Scientific context
  Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
• Bibliography
  1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9. 2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Lysophosphatidic Acid (SIH-403), a Autophagy inhibitor. CAS #: 22556-62-3 . Molecular Formula: C21H41O7P. Molecular Weight: 436.5245 g/mol. Chemical structure of Lysophosphatidic Acid, a Autophagy inhibitor (SIH-403). CAS # 22556-62-3 . Molecular Formula: C21H41O7P.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Lysophosphatidic   Acid   Sodium   Salt   Autophagy   inhibitor  
• Short name
  Lysophosphatidic Acid, Sodium Salt, Autophagy inhibitor
• Alternative name
  Lysophosphatidic Acid, Sodium Salt, Autophagy suppressor

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