LH 846, Casein kinase 1d inhibitor

• Catalog number
  SIH-503-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  639052-78-1
• Description
  Casein kinase 1d inhibitor
• Molecular weight
  316,8 g/mol
• Primary research fields
  Cell Signaling
• Other name
  LH846, LH-846, N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C16H13ClN2OS
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (HPLC)
• Soluble in
  Soluble to 100 mM in DMSO
• Physical appearance
  White to beige powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Acute toxicity, Oral (Category 4) Chronic aquatic toxicity(Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H413 May cause long lasting harmful effects to aquatic life.
• PubChem number
  851474
• Scientific context
  LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm.
• Bibliography
  1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of LH 846 (SIH-503), a Casein kinase 1d inhibitor. CAS #: 639052-78-1. Molecular Formula: C16H13ClN2OS. Molecular Weight: 316.8 g/mol. Chemical structure of LH 846, a Casein kinase 1d inhibitor (SIH-503). CAS # 639052-78-1. Molecular Formula: C16H13ClN2OS.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  846   Casein   kinase   inhibitor  
• Short name
  LH 846, Casein kinase 1d inhibitor
• Alternative name
  LH 846, Casein phosphorylation catalyst 1d suppressor

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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