ICG-001, β-catenin inhibitor

• Catalog number
  SIH-387-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  847591-62-2
• Description
  β-catenin inhibitor
• Molecular weight
  548,63 g/mol
• Primary research fields
  Cell Signaling
• Other name
  (6S,9aS)-Hexahydro-6-[(4-hydroxyphe­nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(­phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c­arboxamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C33H32N4O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO and to 50 mM in ethanol
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
• PubChem number
  11238147
• Scientific context
  Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
• Bibliography
  1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.
• Release date
  17-Jul-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of ICG-001 (SIH-387), a beta-catenin/CBP inhibitor. CAS #: 847591-62-2. Molecular Formula: C33H32N4O4. Molecular Weight: 548.63 g/mol. Chemical structure of ICG-001, a beta-catenin/CBP inhibitor (SIH-387). CAS # 847591-62-2. Molecular Formula: C33H32N4O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  ICG-001   β-catenin   inhibitor  
• Gene symbol
  MTCO1P5, LINC01537, ATP2C2-AS1, OR3A5P, GCASPC
• Short name
  ICG-001, β-catenin inhibitor
• Alternative name
  ICG-001, β-catenin suppressor

Gene info

• Identity
  HGNC:51300
• Gene
  MTCO1P5
• Long gene name
  MT-CO1 pseudogene 5
• Synonyms gene name
  • mitochondrially encoded cytochrome c oxidase I pseudogene 5
• Synonyms
  • AC026166.2-001
• Locus
  3p25.2
• Discovery year
  2014-09-25
• Pubmed identfication
  • 25243407
• VEGA ID
  OTTHUMG00000155369

Gene info

• Identity
  HGNC:51301
• Gene
  LINC01537
• Long gene name
  long intergenic non-protein coding RNA 1537
• Synonyms
  • RP11-169D4.1-001
• GenBank acession
  • AL832797
• Locus
  11q13.4
• Discovery year
  2014-09-25
• Entrez gene record
  101928555
• Pubmed identfication
  • 25243407
  • 31374807
• Classification
  • Long intergenic non-protein coding RNAs
• VEGA ID
  OTTHUMG00000167927

Gene info

• Identity
  HGNC:53167
• Gene
  ATP2C2-AS1
• Long gene name
  ATP2C2 antisense RNA 1
• Synonyms
  • RP11-517C16.2-001
  • RP11-517C16.2
• Locus
  16q24.1
• Discovery year
  2017-03-10
• Entrez gene record
  105371374
• Pubmed identfication
  • 28265570
  • 29712923
• RefSeq identity
  • NR_146503
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:8286
• Gene
  OR3A5P
• Long gene name
  olfactory receptor family 3 subfamily A member 5 pseudogene
• Synonyms gene name
  • olfactory receptor, family 3, subfamily A, member 5 pseudogene
• Synonyms
  • OLFRA06
  • OR25
  • OR17-25
  • RP11-64J4.6-001
• GenBank acession
  • AF087921
• Locus
  17p13.3
• Discovery year
  1998-01-29
• Entrez gene record
  100856809
• Pubmed identfication
  • 8921386
• Classification
  • Olfactory receptors, family 3
• VEGA ID
  OTTHUMG00000185967

Gene info

• Identity
  HGNC:52281
• Gene
  GCASPC
• Long gene name
  gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
• Synonyms
  • TCONS_00011605
  • RP1-56L9.7-001
  • lnc-SOD2-1
• Locus
  6q25.3
• Discovery year
  2016-08-04
• Entrez gene record
  112441427
• Pubmed identfication
  • 27450454
• Classification
  • Long non-coding RNAs with non-systematic symbols

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