Dovitinib, FGFR3 inhibitor
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Catalog number
SIH-500-25MG
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Price
Please ask
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Size
25 mg
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Stock availabilitIn Stock
In Stock
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CAS number
405169-16-6
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Description
FGFR3 inhibitor
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Molecular weight
392,4 g/mol
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Primary research fields
Cell Signaling
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Other name
4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C21H21FN6O
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Origin
Synthetic
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Purity pourcentage
≥98%
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Soluble in
Soluble in DMSO
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Physical appearance
Crystalline solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Target Organ Systemic Toxicity (single exposure), Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. Precautionary statements: P302+352: IF ON SKIN: Wash with plenty of soap and water. P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+313: If eye irritation persists, get medical advice/attention. P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312: Call a {POISON CENTER/doctor/...} if you feel unwell.
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PubChem number
9886808
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Scientific context
Dovitinib is a potent growth factor receptor kinase inhibitor with effects against FLT-3, c-KIT, VEGFR, PDGFRß and CSF-1R.
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Bibliography
1. Konecny G.E., et al. (2013) Mol. Cancer Ther. 12(5): 632–642.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Dovitinib (SIH-500), a FGFR3 inhibitor. CAS #: 405169-16-6. Molecular Formula: C21H21FN6O. Molecular Weight: 392.4 g/mol. Chemical structure of Dovitinib, a FGFR3 inhibitor (SIH-500). CAS # 405169-16-6. Molecular Formula: C21H21FN6O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
FGFR3
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Short name
Dovitinib, FGFR3 inhibitor
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Alternative name
Dovitinib, FGFR3 suppressor
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Gene info
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