Dofetilide , Herg channel blocker

• Catalog number
  SIH-311-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  115256-11-6
• Description
  Herg channel blocker
• Molecular weight
  441,56 g/mol
• Primary research fields
  Neuroscience, Ion Channels
• Other name
  N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide, Tikosyn, UK 68798
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C19H27N3O5S2
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use S57 - Use appropriate containment to avoid environmental contamination Risk Phrases: R22 - Harmful if swallowed R48 - Danger of serious damage to health by prolonged exposure R51/53 - Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment R61 - May cause harm to the unborn child R62 - Possible risk of impaired fertility Hazard Phrases: H302-H319-H360 Precautionary Phrases: P201-P305 + P351 + P338-P308 + P313
• PubChem number
  71329
• Scientific context
  Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).
• Bibliography
  1. Lentz T.L., Hilleman D.E. (2000) Pharmacotherapy. 20(7): 776-786. 2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Dofetilide (SIH-311), a Herg channel blocker. CAS #: 115256-11-6. Molecular Formula: C19H27N3O5S2. Molecular Weight: 441.56 g/mol. Chemical structure of Dofetilide , a Herg channel blocker (SIH-311). CAS # 115256-11-6. Molecular Formula: C19H27N3O5S2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  Dofetilide   Herg   channel   blocker  
• Short name
  Dofetilide , Herg channel blocker
• Alternative name
  Dofetilide , Herg channel blocker

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