DMPQ Dihydrochloride, PDGFRβ kinase inhibitor
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Catalog number
SIH-441-25MG
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Price
Please ask
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Size
25 mg
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Stock availabilitIn Stock
In Stock
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CAS number
137206-97-4
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Description
PDGFRβ kinase inhibitor
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Molecular weight
339,2 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C16H16ClN2O2
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble to 100 mM in water
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Physical appearance
White to beige solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed.
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PubChem number
45073427
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Scientific context
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ). It displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
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Bibliography
1. Dolle R.E., et al. (1994) J. Med. Chem. 37(17): 2627–2629.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of DMPQ Dihydrochloride (SIH-441), a PDGFRbeta kinase inhibitor. CAS #: 137206-97-4. Molecular Formula: C16H16ClN2O2. Molecular Weight: 339.2 g/mol. Chemical structure of DMPQ Dihydrochloride, a PDGFRbeta kinase inhibitor (SIH-441). CAS # 137206-97-4. Molecular Formula: C16H16ClN2O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
PDGFRB
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Short name
DMPQ Dihydrochloride, PDGFRβ kinase inhibitor
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Alternative name
DMPQ Dihydrochloride, PDGFRβ phosphorylation catalyst suppressor
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Gene info
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