AZD6244, ERK kinase inhibitor
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Catalog numberSIH-495-25MG
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Price:
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Size25 mg
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Stock availabilitIn StockIn Stock
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CAS number606143-52-6
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DescriptionERK kinase inhibitor
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Molecular weight457,7 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other nameSelumetinib, AZD6244, 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC17H15BrClFN4O3
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OriginSynthetic
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Purity pourcentage≥98%
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Soluble inSoluble in DMSO (92 mg/ml at 25 °C), water (
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Physical appearanceWhite to off-white solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H318: Causes serious eye damage. H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure. Precautionary statements: P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P302+352: IF ON SKIN: Wash with plenty of soap and water. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.
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PubChem number10127622
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Scientific contextAZD6244 is a MEK-1 inhibitor. Specifically, AZD6244 inactivates the phosphorylation of ERK1/2.
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Bibliography1. Haasbach E., Hartmayer C., & Planz O. (2013) Antiviral Research. 98(2): 319–324.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of AZD6244 (SIH-495), a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol. Chemical structure of AZD6244, a ERK kinase inhibitor (SIH-495). CAS # 606143-52-6. Molecular Formula: C17H15BrClFN4O3.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.025
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolEPHB2, MAPK1
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Short nameAZD6244, ERK kinase inhibitor
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Alternative nameAZD6244, ERK phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene nameEPH receptor B2
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Synonyms gene
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Synonyms gene name
- EphB2
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- EPH receptors
- MicroRNA protein coding host genes
- Sterile alpha motif domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 1
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-11-05
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Entrez gene record
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Classification
- Mitogen-activated protein kinases
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VEGA ID
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Locus Specific Databases