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Stock availabilitIn Stock
In Stock
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CAS number
5142-23-4
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Description
Autophagosome inhibitor
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Molecular weight
149,2 g/mol
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Primary research fields
Cancer, Autophagy
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Other name
3-MA, 3-Methyl-3H-purin-6-amine
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C6H7N5
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Origin
Synthetic
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Purity pourcentage
≥98%
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Soluble in
Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
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Physical appearance
White solid.
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
1673
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Scientific context
3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
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Bibliography
1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6. 2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64. 3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.
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Release date
31-Mar-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of 3-Methyladenine (SIH-408), a Autophagosome inhibitor. CAS #: 5142-23-4. Molecular Formula: C6H7N5. Molecular Weight: 149.2 g/mol. Chemical structure of 3-Methyladenine, a Autophagosome inhibitor (SIH-408). CAS # 5142-23-4. Molecular Formula: C6H7N5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.1
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.