Recombinant Salmonella typhi LPS-assembly protein LptD(lptD),partial
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Catalog number
AP74277-10ug
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Price
Please ask
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Size
10ug
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Similar name
LPS-assembly protein LptD(lptD),partial
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Other name
Recombinant Salmonella typhi LPS-assembly protein LptD(lptD),partial Expressed in Yeast
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Synonym
Recombinant LPS-assembly protein LptD(lptD),partial
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Little description
Our LPS-assembly protein LptD(lptD),partial is a recombinant Salmonella typhi protein expressed in Yeast with N-terminal 6xHis-tagged
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Expression system
Yeast
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Origin species
Salmonella typhi
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Conjugation
N-terminal 6xHis-tagged
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Storage
For long term storage, keep the Recombinant Salmonella typhi LPS-assembly protein LptD(lptD),partial frozen at -20 or -80 degrees Celsius. Working aliquots can be stored at +4C for a few weeks. We recommend cycles of freezing and thawing to be avoided, as they will most certainly denaturate the polypeptide chains of the protein.
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Shipping
The Salmonella typhi LPS-assembly protein LptD(lptD),partial is shipped on ice packs.
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Gene
Bacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A. The lipid A component is the primary immunostimulatory center of LPS. With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types. In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species. Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock. Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system. During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes. According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IRF6
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Short name
Recombinant Salmonella typhi LPS-assembly protein LptD(lptD),partial
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. SAB advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Salmonella, Salmonellas
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Alternative name
Salmonella typhi LPS-assembly protein LptD(lptD),partial
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Alternative technique
rec
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Disease
Salmonella typhimurium, enteriditis and Salmonella paratyphi antibodies or media detect this rod-shaped (bacillus) gram-negative bacteria of the Enterobacteriaceae family. The two species of Salmonella are Salmonella enterica and Salmonella bongori. Salmonella enterica is the type species and is further divided into six subspecies that include over 2500 serovars.
S. enterica subspecies are found worldwide in all warm-blooded animals, and in the environment. S. bongori is restricted to cold-blooded animals particularly reptiles. Strains of Salmonella cause illnesses such as typhoid fever, paratyphoid fever, and food poisoning (salmonellosis).
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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