TGF-Beta3 Recombinant Protein

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• Catalog number
  40-574
• Price:

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• Size
  0.01 mg

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• About recombinant protein
  The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Manufactured using all non-animal reagents.
• Other name of the recombinant
  ARVD, RNHF, ARVD1, TGF-beta3, Transforming growth factor beta-3, TGF-beta-3
• Recombinant in
  E. coli
• His tag on the recombinant protein
  no His tag
• SEQUENCE
  ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
• Activity
  Biological activity was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥2 x 107 units/mg. Endotoxin level is less than 0.1 ng per μg of TGF-β3 (1EU/μg).
• Keep at
  The lyophilized TGF-Beta3 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted TGF-Beta3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing TGF-Beta3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4507465
• Accession nr
  NP_003230.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  7043
• Gene name
  transforming growth factor, beta 3
• Source
  Homo sapiens
• Uniprot
  P10600
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

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• Gene target
  TGF-Beta3   Protein  
• Gene symbol
  TGFB3
• Short name
  TGF-Beta3 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  TGF-Beta3 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11769
• Gene
  TGFB3
• Long gene name
  transforming growth factor beta 3
• Synonyms gene
  • ARVD1
  • ARVD
• Synonyms gene name
  • arrhythmogenic right ventricular dysplasia 1
  • transforming growth factor, beta 3
• Synonyms name
  • prepro-transforming growth factor beta-3
• Locus
  14q24.3
• Discovery year
  1989-05-10
• Entrez gene record
  7043
• Pubmed identfication
  • 16549496
  • 15639475
• RefSeq identity
  • NM_003239
• Classification
  • Transforming growth factor beta family
• VEGA ID
  OTTHUMG00000171489
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_399

Gene info

• Identity
  HGNC:53144
• Gene
  TGFB3-AS1
• Long gene name
  TGFB3 antisense RNA 1
• Synonyms
  • ENST00000553732
• Locus
  14q24.3
• Discovery year
  2017-02-16
• Pubmed identfication
  • 27816668
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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