sDLL-4 Recombinant Protein

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• Catalog number
  40-235
• Price:

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• Size
  0.005 mg, 0.025 mg

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• About recombinant protein
  Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.
• Other name of the recombinant
  hdelta2, Delta-like protein 4, Drosophila Delta homolog 4, Delta4
• Recombinant in
  HEK293 cells
• SEQUENCE
  SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP
• Activity
  The sDLL - 4, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells.
• Keep at
  The lyophilized sDLL-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing sDLL-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  9506545
• Accession nr
  NP_061947.1
• Pureity
  Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  54567
• Gene name
  delta-like 4 (Drosophila)
• Source
  Homo sapiens
• Uniprot
  Q9NR61
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

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• Gene target
  sDLL-4   Protein  
• Gene symbol
  DLL4
• Short name
  sDLL-4 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  sDLL-4 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:2910
• Gene
  DLL4
• Long gene name
  delta like canonical Notch ligand 4
• Synonyms gene name
  • delta-like 4 homolog (Drosophila)
  • delta-like 4 (Drosophila)
• GenBank acession
  • AF253468
• Locus
  15q15.1
• Discovery year
  2000-07-31
• Entrez gene record
  54567
• Pubmed identfication
  • 10837024
• VEGA ID
  OTTHUMG00000172511
• Locus Specific Databases
  • LRG_1268

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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