MyD88 Fragment Recombinant Protein
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Catalog number
95-104
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Price
Please ask
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Size
0.05 mg
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About recombinant protein
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
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Other name of the recombinant
MyD88 Antibody : MYD88D
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Recombinant in
E. coli
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His tag on the recombinant protein
Fusion Partner: His-tag and streptavidin II-tag at N-terminus
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SEQUENCE
aa 176 - 280
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Activity
not available
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Use of recmbinant
This recombinant protein can be used for WB, ELISA, MS. For research use only.
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Protein is used in
E, WB, MS
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Suspention medium
1X PBS containing 0.1% SDS and 0.02% NaN3
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Keep at
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
1814020
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Accession nr
AAC50954
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KDa of reombinant
15 kDa (Calculated)
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Pureity
~95%
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About
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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Vial
Liquid
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NCBI ID
4615
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Gene name
myeloid differentiation primary response gene (88)
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Source
Homo sapiens
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Uniprot
Q99836
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
MYD88
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Short name
MyD88 Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Isotype
Antibody fragments and scFv fragments, single chain variable fragments can be E. coli expressed. Fragment peptides for polyclonals give monoclonal like antibodies as the epitope is very small. IgG Fc and(ab)2 fragments are small and stable subunits of the antibody obtained by enzymatic digestion. Complement fragments, bp DNA fragments are common.
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Alternative name
myeloid differentiation primary response 88 Fragment Rec. Protein
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Alternative technique
rec
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Alternative to gene target
myeloid differentiation primary response 88, MYD88D, MYD88 and IDBG-25713 and ENSG00000172936 and 4615, TIR domain binding, Plasma membranes, Myd88 and IDBG-204565 and ENSMUSG00000032508 and 17874, MYD88 and IDBG-644299 and ENSBTAG00000000563 and 444881
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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