IRAK Recombinant Protein

• Catalog number
  95-112
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  Nuclear factor kappa B (NF-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
• Other name of the recombinant
  IRAK Antibody: IRAK, pelle, IRAK, Interleukin-1 receptor-associated kinase 1, IRAK-1
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: C-terminal His-tag
• SEQUENCE
  aa 618 - 712
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
• Protein is used in
  E, WB, MS
• Suspention medium
  100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  8928535
• Accession nr
  P51617
• KDa of reombinant
  15 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Vial
  Liquid
• NCBI ID
  3654
• Gene name
  interleukin-1 receptor-associated kinase 1
• Source
  Homo sapiens
• Uniprot
  P51617
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IRAK   Protein  
• Gene symbol
  IRAK1
• Short name
  IRAK Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  IRAK Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6112
• Gene
  IRAK1
• Long gene name
  interleukin 1 receptor associated kinase 1
• Synonyms
  • IRAK
  • pelle
• GenBank acession
  • L76191
• Locus
  Xq28
• Discovery year
  1998-06-22
• Entrez gene record
  3654
• Pubmed identfication
  • 9374458
  • 8599092
• VEGA ID
  OTTHUMG00000024228
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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