IL-4 Recombinant Protein
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Catalog number40-604
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PricePlease ask
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Size0.02 mg
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About recombinant proteinIL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.
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Other name of the recombinantBSF1, IL-4, BCGF1, BSF-1, BCGF-1, Interleukin-4, B-cell stimulatory factor 1
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Recombinant inE. coli
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His tag on the recombinant proteinno His tag
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SEQUENCEMHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
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ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 0.2 ng/mL, corresponding to a specific activity of = 5 x 106 units/mg.
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Keep atThe lyophilized IL-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI4504669
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Accession nrNP_000580.1
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PureityGreater than 98% by SDS-PAGE gel and HPLC analyses.
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AboutThis product is for research use only.
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Protein s originHuman
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VialLyophilized
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NCBI ID3565
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Gene nameinterleukin 4
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SourceHomo sapiens
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UniprotP05112
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolIL4
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Short nameIL-4 Recombinant Protein
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameInterleukin-4 Rec. Protein
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1988-08-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data