IL-13 Variant Recombinant Protein

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• Catalog number
  40-259
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• Size
  0.002 mg, 0.01 mg

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• About recombinant protein
  IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. This genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
• Other name of the recombinant
  P600, IL-13, NC30, Interleukin-13
• Recombinant in
  E. coli
• SEQUENCE
  MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
• Activity
  This IL - 13 analog shows a two fold increase, relative to wild type IL - 13, in bioactivity as measured by the in - vitro dose dependent activation of STAT6 and IL - 13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL - 13, as measured by the induction of airway hyper - responsiveness.
• Keep at
  The lyophilized IL-13 Variant recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-13 Variant is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-13 Variant recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  26787978
• Accession nr
  NP_002179.2
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  3596
• Gene name
  interleukin 13
• Source
  Homo sapiens
• Uniprot
  P35225
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

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• Gene target
  IL-13   Variant   Protein  
• Gene symbol
  IL13
• Short name
  IL-13 Variant Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Interleukin-13 Variant Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:5973
• Gene
  IL13
• Long gene name
  interleukin 13
• Synonyms
  • P600
  • IL-13
  • ALRH
  • BHR1
  • MGC116786
  • MGC116788
  • MGC116789
• Synonyms name
  • allergic rhinitis
  • Bronchial hyperresponsiveness-1 (bronchial asthma)
• GenBank acession
  • U31120
• Locus
  5q31.1
• Discovery year
  1993-04-07
• Entrez gene record
  3596
• RefSeq identity
  • NM_002188
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000059723

MeSH Data

• Name
  Radioimmunosorbent Test
• Concept
  Scope note: Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
• Tree numbers
  • E05.478.566.380.830
  • E05.478.566.639.830
  • E05.601.470.380.830
  • E05.601.470.639.830
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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