IL-13 Variant Recombinant Protein
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Catalog number40-259
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Price:
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Size0.002 mg, 0.01 mg
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About recombinant proteinIL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. This genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
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Other name of the recombinantP600, IL-13, NC30, Interleukin-13
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Recombinant inE. coli
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SEQUENCEMSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
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ActivityThis IL - 13 analog shows a two fold increase, relative to wild type IL - 13, in bioactivity as measured by the in - vitro dose dependent activation of STAT6 and IL - 13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL - 13, as measured by the induction of airway hyper - responsiveness.
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Keep atThe lyophilized IL-13 Variant recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-13 Variant is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-13 Variant recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI26787978
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Accession nrNP_002179.2
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PureityGreater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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AboutThis product is for research use only.
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Protein s originHuman
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VialLyophilized
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NCBI ID3596
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Gene nameinterleukin 13
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SourceHomo sapiens
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UniprotP35225
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolIL13
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Short nameIL-13 Variant Recombinant Protein
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameInterleukin-13 Variant Rec. Protein
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 13
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-04-07
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Entrez gene record
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
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Tree numbers
- E05.478.566.380.830
- E05.478.566.639.830
- E05.601.470.380.830
- E05.601.470.639.830
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Qualifiersethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data