Hemagglutinin Recombinant Protein
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Catalog number
95-101
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Price
Please ask
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Size
0.05 mg
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About recombinant protein
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, but it is in birds that all subtypes can be found (2). These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with host cell surface proteins containing oligosaccharides with terminal sialyl residues. Its extracellular region has two domains (HA1 and HA2); HA1 is cleaved from the main hemagglutinin protein by the host immune system. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong (3). This more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the efficiency of this type of transmission is low (4). Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability (5). This HA1 recombinant protein is recognized by several ProSci hemagglutinin antibodies.
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Other name of the recombinant
H5N1 Hemagglutinin HA1, H5N1 Hemagglutinin, H5N1 HA1, HA1
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Recombinant in
E. coli
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His tag on the recombinant protein
Fusion Partner: His-tag and streptavidin II-tag at N-terminus
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SEQUENCE
aa. 17 - 338
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Activity
not available
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Use of recmbinant
This recombinant protein can be used for WB, ELISA, MS. For research use only.
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Protein is used in
E, WB, MS
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Suspention medium
1X PBS containing 0.1% SDS and 0.02% NaN3
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Keep at
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
50365729
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Accession nr
AAT76166
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KDa of reombinant
39 kDa (Calculated)
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Pureity
~95%
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About
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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Vial
Liquid
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NCBI ID
3654620
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Gene name
Hemagglutinin
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Source
Influenza A virus (A/chicken/Jilin/9/2004(H5N1))
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Uniprot
Q692M2
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
HA
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Short name
Hemagglutinin Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative name
Hemagglutinin Rec. Protein
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
myosin IG
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2000-11-28
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Entrez gene record
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Classification
- Myosin heavy chains, class I
- Minor histocompatibility antigens
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VEGA ID
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
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Tree numbers
- E01.370.225.812.735.050.375
- E05.200.812.735.050.375
- E05.478.594.760.050.375
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Qualifiers
ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data
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