GDF-5 Recombinant Protein

• Catalog number
  40-579
• Price
  Please ask
• Size
  0.01 mg, 0.05 mg

• About recombinant protein
  GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
• Other name of the recombinant
  OS5, LAP4, BDA1C, BMP14, CDMP1, SYM1B, SYNS2, Cartilage-derived morphogenetic protein 1, GDF-5
• Recombinant in
  E. coli
• SEQUENCE
  APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
• Activity
  Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• Keep at
  The lyophilized GDF-5 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted GDF-5 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing GDF-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4503969
• Accession nr
  NP_000548.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.
• About
  This product is for research use only.
• Protein s origin
  Murine
• Vial
  Lyophilized
• NCBI ID
  8200
• Gene name
  growth differentiation factor 5
• Source
  Homo sapiens
• Uniprot
  P43026
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  GDF-5   Protein  
• Gene symbol
  GDF5
• Short name
  GDF-5 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  GDF-5 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4220
• Gene
  GDF5
• Long gene name
  growth differentiation factor 5
• Synonyms
  • CDMP1
  • BMP14
• Synonyms name
  • cartilage-derived morphogenetic protein-1
• GenBank acession
  • X80915
• Locus
  20q11.22
• Discovery year
  1997-12-05
• Entrez gene record
  8200
• Pubmed identfication
  • 9288091
  • 9288098
• Classification
  • Transforming growth factor beta superfamily
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000032341

Gene info

• Identity
  HGNC:33435
• Gene
  GDF5-AS1
• Long gene name
  GDF5 antisense RNA 1
• Synonyms gene
  • GDF5OS
• Synonyms gene name
  • growth differentiation factor 5 opposite strand
• GenBank acession
  • BC085019
• Locus
  20q11.22
• Discovery year
  2007-04-12
• Entrez gene record
  554250
• RefSeq identity
  • NR_161326
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000055985

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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