Epiregulin Recombinant Protein

• Catalog number
  40-149
• Price
  Please ask
• Size
  0.005 mg, 0.025 mg

• About recombinant protein
  Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.
• Other name of the recombinant
  ER, Proepiregulin, EPR
• Recombinant in
  E. coli
• SEQUENCE
  MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
• Activity
  The ED50 was determined by its ability to inhibit IGF - II induced proliferation of MCF - 7 is ≤ 0.3 μg/mL in the presence of 15 ng/mL of human IGF - II.
• Keep at
  The lyophilized Epiregulin recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Epiregulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Epiregulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4557567
• Accession nr
  NP_001423.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  2069
• Gene name
  epiregulin
• Source
  Homo sapiens
• Uniprot
  O14944
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Epiregulin   Protein  
• Gene symbol
  EREG
• Short name
  Epiregulin Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Epiregulin Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:3443
• Gene
  EREG
• Long gene name
  epiregulin
• Synonyms
  • ER
• GenBank acession
  • D30783
• Locus
  4q13.3
• Discovery year
  1998-02-11
• Entrez gene record
  2069
• Pubmed identfication
  • 9337852
• VEGA ID
  OTTHUMG00000130005

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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