DKK-1 Recombinant Protein

• Catalog number
  40-225
• Price
  Please ask
• Size
  0.002 mg, 0.01 mg

• About recombinant protein
  DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
• Other name of the recombinant
  SK, DKK-1, Dickkopf-related protein 1, SK, Dickkopf-1
• Recombinant in
  HEK293 cells
• SEQUENCE
  TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH
• Keep at
  The lyophilized DKK-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted DKK-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing DKK-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  7110719
• Accession nr
  NP_036374.1
• Pureity
  Greater than 97% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  22943
• Gene name
  dickkopf WNT signaling pathway inhibitor 1
• Source
  Homo sapiens
• Uniprot
  O94907
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  DKK-1   Protein  
• Gene symbol
  DKK1
• Short name
  DKK-1 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  DKK-1 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:2891
• Gene
  DKK1
• Long gene name
  dickkopf WNT signaling pathway inhibitor 1
• Synonyms gene name
  • dickkopf (Xenopus laevis) homolog 1
  • dickkopf 1 homolog (Xenopus laevis)
• Synonyms
  • SK
  • DKK-1
• Locus
  10q21.1
• Discovery year
  2000-09-01
• Entrez gene record
  22943
• RefSeq identity
  • NM_012242
• VEGA ID
  OTTHUMG00000018247

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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