BMP-4 Recombinant Protein

• Catalog number
  40-549
• Price
  Please ask
• Size
  0.01 mg

• About recombinant protein
  Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. ProSci’s E.coli derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.
• Other name of the recombinant
  ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP-4
• Recombinant in
  E. coli
• His tag on the recombinant protein
  no His tag
• SEQUENCE
  KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
• Activity
  Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/mL. Endotoxin level is less than 0.1 ng per μg of BMP-4 (1EU/μg).
• Keep at
  The lyophilized BMP-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted BMP-4 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing BMP-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  157276593
• Accession nr
  NP_001193.2
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  652
• Gene name
  bone morphogenetic protein 4
• Source
  Homo sapiens
• Uniprot
  P12644
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BMP-4   Protein  
• Gene symbol
  BMP4
• Short name
  BMP-4 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  BMP-4 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:1071
• Gene
  BMP4
• Long gene name
  bone morphogenetic protein 4
• Synonyms gene
  • BMP2B
• GenBank acession
  • AF035427
• Locus
  14q22.2
• Discovery year
  1990-06-11
• Entrez gene record
  652
• Pubmed identfication
  • 7558046
  • 7579580
• RefSeq identity
  • NM_001202
• Classification
  • Bone morphogenetic proteins
• VEGA ID
  OTTHUMG00000140303

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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