APRIL Recombinant Protein

• Catalog number
  40-302
• Price
  Please ask
• Size
  0.002 mg, 0.01 mg

• About recombinant protein
  APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.
• Other name of the recombinant
  APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand
• Recombinant in
  High-5 Insect cells
• SEQUENCE
  AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
• Activity
  Tested by its ability to induce IgM secretion by CpG/CD40L treated human naive B cells, at a concentration of 500 ng/mL.
• Keep at
  The lyophilized APRIL recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted APRIL is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing APRIL recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  310750385
• Accession nr
  NP_001185551.1
• Pureity
  Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  8741
• Gene name
  tumor necrosis factor (ligand) superfamily, member 13
• Source
  Homo sapiens
• Uniprot
  O75888
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  APRIL   Protein  
• Gene symbol
  TNFSF13
• Short name
  APRIL Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  APRIL Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11928
• Gene
  TNFSF13
• Long gene name
  TNF superfamily member 13
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 13
• Synonyms
  • APRIL
  • CD256
• GenBank acession
  • AF046888
• Locus
  17p13.1
• Discovery year
  1998-12-04
• Entrez gene record
  8741
• Pubmed identfication
  • 9743536
• RefSeq identity
  • NM_003808
• Classification
  • Tumor necrosis factor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000108145

Gene info

• Identity
  HGNC:33537
• Gene
  TNFSF12-TNFSF13
• Long gene name
  TNFSF12-TNFSF13 readthrough
• Synonyms
  • TWE-PRIL
• GenBank acession
  • AY081051
• Locus
  17p13.1
• Discovery year
  2007-07-31
• Entrez gene record
  407977
• Pubmed identfication
  • 12411489
• VEGA ID
  OTTHUMG00000161573

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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