ApoA-I Recombinant Protein

• Catalog number
  40-139
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• About recombinant protein
  ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the "good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.
• Other name of the recombinant
  Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
• Recombinant in
  E. coli
• SEQUENCE
  MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ
• Keep at
  The lyophilized ApoA-I recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted ApoA-I is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing ApoA-I recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4557321
• Accession nr
  NP_000030.1
• Pureity
  Greater than 97% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  335
• Gene name
  apolipoprotein A-I
• Source
  Homo sapiens
• Uniprot
  P02647
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ApoA-I   Protein  
• Gene symbol
  APOA1
• Short name
  ApoA-I Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  ApoA-I Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:600
• Gene
  APOA1
• Long gene name
  apolipoprotein A1
• Synonyms gene name
  • apolipoprotein A-I
• GenBank acession
  • X02162
• Locus
  11q23.3
• Discovery year
  2001-06-22
• Entrez gene record
  335
• RefSeq identity
  • NM_000039
• Classification
  • Apolipoproteins
• VEGA ID
  OTTHUMG00000046112
• Locus Specific Databases
  • LRG_767

Gene info

• Identity
  HGNC:40079
• Gene
  APOA1-AS
• Long gene name
  APOA1 antisense RNA
• GenBank acession
  • DA327409
• Locus
  11q23.3
• Discovery year
  2014-01-04
• Entrez gene record
  104326055
• Pubmed identfication
  • 24388749
• RefSeq identity
  • NR_126362
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150649

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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