anti-ZP3 Antibody

• Catalog number
  28-372
• Price
  Please ask
• Size
  100 ug

• Gene info
  The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene
• Gene names
  ZP3, ZPC, ZP3A, ZP3B, Zp-3
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by protein A chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZP3.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  ZP3 antibody can be used for detection of ZP3 by ELISA at 1:62500. ZP3 antibody can be used for detection of ZP3 by western blot at 0.6 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store ZP3 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human
• Omim nr
  251757420
• Ncbi nr
  P21754-2
• KDa
  47 kDa, 23 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  7784
• GENE symbol
  ZP3
• Antigene name
  zona pellucida glycoprotein 3 (sperm receptor)
• Source
  Homo sapiens
• Protein nr
  P21754-2
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ZP3  
• Gene symbol
  ZP3, POMZP3
• Short name
  anti-ZP3 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toZP3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:13189
• Gene
  ZP3
• Long gene name
  zona pellucida glycoprotein 3
• Synonyms gene
  • ZP3A
  • ZP3B
• Synonyms gene name
  • zona pellucida glycoprotein 3A (sperm receptor)
• Synonyms
  • ZP3-424
  • ZP3-372
  • ZPC
• GenBank acession
  • M60504
• Locus
  7q11.23
• Discovery year
  1991-07-31
• Entrez gene record
  7784
• Pubmed identfication
  • 1478648
• Classification
  • Zona pellucida glycoproteins
• VEGA ID
  OTTHUMG00000130575

Gene info

• Identity
  HGNC:9203
• Gene
  POMZP3
• Long gene name
  POM121 and ZP3 fusion
• Synonyms gene name
  • POM (POM121 rat homolog) and ZP3 fusion
  • POM (POM121 homolog, rat) and ZP3 fusion
• Synonyms
  • POM-ZP3
  • POM121
• Synonyms name
  • POM-ZP3 fusion protein
  • POM121/ZP3 fusion protein
• GenBank acession
  • U10099
• Locus
  7q11.23
• Discovery year
  2000-03-20
• Entrez gene record
  22932
• Pubmed identfication
  • 7789967
• RefSeq identity
  • NM_012230
• VEGA ID
  OTTHUMG00000023514

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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