anti-UPF3B Antibody

• Catalog number
  29-462
• Price
  Please ask
• Size
  100 ug

• Gene info
  UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
• Gene names
  UPF3B, MRX62, UPF3X, HUPF3B, MRXS14, RENT3B
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by protein A chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UPF3B.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  UPF3B antibody can be used for detection of UPF3B by ELISA at 1:312500. UPF3B antibody can be used for detection of UPF3B by western blot at 1.25 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store UPF3B antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human, Dog
• Omim nr
  12711674
• Ncbi nr
  NP_075386
• KDa
  52 kDa, 58 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  65109
• GENE symbol
  UPF3B
• Antigene name
  UPF3 regulator of nonsense transcripts homolog B (yeast)
• Source
  Homo sapiens
• Protein nr
  Q9BZI7
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  UPF3B  
• Gene symbol
  UPF3B
• Short name
  anti-UPF3B Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toUPF3B (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:20439
• Gene
  UPF3B
• Long gene name
  UPF3B regulator of nonsense mediated mRNA decay
• Synonyms gene
  • MRX62
  • UPF3BP1
  • UPF3BP2
  • UPF3BP3
• Synonyms gene name
  • mental retardation, X-linked 62
  • UPF3B pseudogene 1
  • UPF3B pseudogene 2
  • UPF3B pseudogene 3
  • UPF3 regulator of nonsense transcripts homolog B (yeast)
  • UPF3B, regulator of nonsense mediated mRNA decay
• Synonyms
  • RENT3B
  • UPF3X
  • HUPF3B
  • MRX82
• GenBank acession
  • AF318576
• Locus
  Xq24
• Discovery year
  2003-02-07
• Entrez gene record
  65109
• Pubmed identfication
  • 11113196
  • 11163187
  • 19238151
• RefSeq identity
  • NM_080632
• Classification
  • DECID complex
• VEGA ID
  OTTHUMG00000022282
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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