anti-Slug Antibody

• Catalog number
  3957
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Slug Antibody: Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
• Gene names
  Slug Antibody: SLUG, WS2D, SLUGH1, SNAIL2, SLUG, SLUGH, Zinc finger protein SNAI2, Neural crest transcription factor Slug
• Antibodie s label
  unlabelled serum
• Purity
  Slug Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  Slug antibody was made against a 14 amino acid synthetic peptide from near the center of human Slug.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  Slug antibody can be used for detection of Slug by Western blot at 1 to 2 ug/mL.
• Suspention pH azide
  Slug Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Slug antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  11134406
• Ncbi nr
  O43623
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  6591
• GENE symbol
  SNAI2
• Antigene name
  snail homolog 2 (Drosophila)
• Source
  Homo sapiens
• Protein nr
  O43623
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Slug  
• Gene symbol
  SNAI2
• Short name
  anti-Slug Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSlug (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11094
• Gene
  SNAI2
• Long gene name
  snail family transcriptional repressor 2
• Synonyms gene
  • SLUG
• Synonyms gene name
  • slug homolog, zinc finger protein (chicken)
  • snail homolog 2 (Drosophila)
  • snail family zinc finger 2
• Synonyms
  • SLUGH1
  • SNAIL2
  • SLUGH
• GenBank acession
  • U97060
• Locus
  8q11.21
• Discovery year
  1998-07-03
• Entrez gene record
  6591
• Pubmed identfication
  • 9337409
  • 9721220
• RefSeq identity
  • NM_003068
• Classification
  • Zinc fingers C2H2-type
  • SNAG transcriptional repressors
• VEGA ID
  OTTHUMG00000149912
• Locus Specific Databases
  • LRG_1359

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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