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Gene info
PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9
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Gene names
PSMC3, TBP1
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Antibodie s label
unlabelled serum
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Purity
Antibody is purified by protein A chromatography method.
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PSMC3.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry
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Antibody advice
PSMC3 antibody can be used for detection of PSMC3 by ELISA at 1:312500. PSMC3 antibody can be used for detection of PSMC3 by western blot at 1.25 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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Suspention pH azide
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.
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Keep at
For short periods of storage (days) store at 4 grades C. For longer periods of storage, store PSMC3 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
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Works with
Human, Mouse, Dog
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Omim nr
21361144
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Ncbi nr
NP_002795
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KDa
45 kDa
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Vial with antibody
Lyophilized
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Quantity per ml
1 mg/ml
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NCBI GENE nr
5702
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GENE symbol
PSMC3
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Antigene name
proteasome (prosome, macropain) 26S subunit, ATPase, 3
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Source
Homo sapiens
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Protein nr
Q6IBS1
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PSMC3
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Short name
anti-PSMC3 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toPSMC3 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
proteasome (prosome, macropain) 26S subunit, ATPase, 3, TBP1, PSMC3 and IDBG-43355 and ENSG00000165916 and 5702, nucleoside-triphosphatase activity, nuclei, Psmc3 and IDBG-190080 and ENSMUSG00000002102 and 19182, PSMC3 and IDBG-637440 and ENSBTAG00000021744 and 508448
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