anti-PILRB Antibody
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Catalog number26-179
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PricePlease ask
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Size50 ug
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Gene infoPaired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.
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Gene namesPILRB, FDFACT1, FDFACT2
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Antibodie s labelunlabelled serum
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PurityAntibody is purified by peptide affinity chromatography method.
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Ab raised inRabbit
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TypePolyclonal
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AntigenAntibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PILRB.
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Immuno applicationELISA, Western Blot
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Antibody advicePILRB antibody can be used for detection of PILRB by ELISA at 1:312500. PILRB antibody can be used for detection of PILRB by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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Suspention pH azideAntibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
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Keep atFor short periods of storage (days) store at 4 grades C. For longer periods of storage, store PILRB antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
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Works withHuman
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Omim nr30179915
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Ncbi nrNP_038468
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KDa23 kDa
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Vial with antibodyLyophilized
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Quantity per ml1 mg/ml
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NCBI GENE nr29990
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GENE symbolPILRB
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Antigene namepaired immunoglobin-like type 2 receptor beta
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SourceHomo sapiens
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Protein nrQ9UKJ0
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPILRB, STAG3L5P-PVRIG2P-PILRB
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Short nameanti-PILRB Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toPILRB (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namepaired immunoglobin like type 2 receptor beta
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Synonyms gene name
- paired immunoglobin-like type 2 receptor beta
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-09-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSTAG3L5P-PVRIG2P-PILRB readthrough
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Locus
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Discovery year2013-06-26
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Entrez gene record
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data