anti-ORAI3 Antibody [2H2G9]
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Catalog number
PM-4911
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Price
Please ask
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Size
0.02 mg, 0.1 mg
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Gene info
ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
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Gene names
ORAI3 Antibody [2H2G9] : TMEM142C
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Antibodie s label
unlabelled serum
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Purity
ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
2H2G9
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Immunoglobulin
IgG2a
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Antigen
A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
ORAI3 antibody can be used for detection of ORAI3 by Western blot at 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 5 ug/mL.
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Suspention pH azide
ORAI3 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
ORAI3 monoclonal antibody can be stored at -20 grades C, stable for one year.
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Works with
Human, Rat
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Omim nr
74732916
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Ncbi nr
Q9BRQ5
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
93129
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GENE symbol
ORAI3
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Antigene name
ORAI calcium release-activated calcium modulator 3
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Source
homo sapiens
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Protein nr
Q9BRQ5
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ORAI3
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Short name
anti-ORAI3 Antibody [2H2G9]
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toORAI3 (antibody to-) [2H2G9]
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Alternative technique
antibodies
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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