anti-NCR1 Antibody [N1d9]
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Catalog number
49-356
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Price
Please ask
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Size
0.05 mg
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Gene info
Recognises the human natural cytotoxicity receptor CD335, also known as NKp46. NKp46 is expressed on circulating NK cells and is reported to be a novel NK-specific cell surface molecule that is involved in human NK cell activation. Natural killer (NK) cells contribute to the innate immune response by directly lysing a variety of tumour cells and cells that are infected by viruses. Natural cytotoxicity receptors (NCR) are a family of Ig-like activation receptors that are reported to play an important role in tumour cell recognition. Three NCR have been reported to-date, which include NKp46, NKp30 and NKp44. The ligands for these NCR have not been identified. NKp46/CD335 is expressed on activated and resting NK cells but not on T or B cells and belongs to a family of receptors termed natural cytotoxicity receptors (NCR). Their engagement induces a strong activation of NK-mediated cytolysis and direct correlation exists between the surface density of NCR and the ability of NK cells to kill various target cells.
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Gene names
NCR1, CD335, HNKp46, NK-p46, Lymphocyte antigen 94 homolog, NK cell-activating receptor, CD335 antigen, LY94, NKP46
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Antibodie s label
unlabelled serum
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Purity
Protein G Column
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
[N1d9]
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Immunoglobulin
IgG1
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Antigen
NCR1 monoclonal antibody was made against recombinant full length NCR1 (Human).
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Immuno application
Western Blot, immuno-histo-chemistry, FLOW
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Antibody advice
NCR1 antibody can be used in Western Blot starting at 2 - 4 ug/mL, immunohistochemistry starting at 1:100, and immunoprecipitation.
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Suspention pH azide
PBS, pH 7.4, 0.09% sodium azide.
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Keep at
Store NCR1 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles. Store undiluted.
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Works with
Human
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Omim nr
47605775
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Ncbi nr
O76036
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Vial with antibody
in solution
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NCBI GENE nr
9437
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GENE symbol
NCR1
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Antigene name
natural cytotoxicity triggering receptor 1
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Source
Homo sapiens
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Protein nr
O76036
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
NCR1
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Short name
anti-NCR1 Antibody [N1d9]
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toNCR1 (antibody to-) [N1d9]
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Alternative technique
antibodies
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Alternative to gene target
natural cytotoxicity triggering receptor 1, CD335 and LY94 and NK-p46 and NKP46, NCR1 and IDBG-69753 and ENSG00000189430 and 9437, receptor signaling protein activity, Plasma membranes, Ncr1 and IDBG-137680 and ENSMUSG00000062524 and 17086, NCR1 and IDBG-641998 and ENSBTAG00000045529 and 369024
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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