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Gene info
Human MUC-1 : This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. Also known as Cancer-associated Antigen 15-3 (CA15-3).
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Gene names
MUC1, CA15-3, CD227, Carcinoma-associated mucin, CD227 antigen, DF3 antigen, Episialin, Epithelial membrane antigen, H23 antigen, H23AG, Krebs von den Lungen-6, MAM6, MUC1/ZD, MUC-1/SEC, Mucin-1, Pem, KL-6, MUC-1/X, Tumor-associated mucin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, PUM, EMA, MUC-1, Mucin 1, transmembrane
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Antibodie s label
unlabelled serum
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Purity
Protein A Column
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Ab raised in
Mouse
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Type
Monoclonal
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Immunoglobulin
IgG1
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Spicific to
Reactive to human MUC-1 peptide repeat RPAP region.
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Antigen
Mucin 1 monoclonal antibody was made against a peptide located in the peptide repeat RPAP region of Mucin 1 (Human).
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Immuno application
ELISA, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
Mucin 1 antibody can be used in ELISA, and immunohistochemistry starting at 2.5 - 5 ug/mL.
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Suspention pH azide
TBS, pH 7.5, 0.05% sodium azide.
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Keep at
For long term storage of Mucin 1 antibody add glycerol (40-50%) and store at -20 grades C. For short term store at 4 grades C.
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Works with
Human
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Omim nr
296439295
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Ncbi nr
P15941
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Vial with antibody
in solution
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NCBI GENE nr
4582
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GENE symbol
MUC1
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Antigene name
mucin 1, cell surface associated
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Source
Homo sapiens
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Protein nr
P15941
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translation
anticorps
