anti-MKRN1 Antibody

• Catalog number
  29-840
• Price
  Please ask
• Size
  100 ug

• Gene info
  The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
• Gene names
  MKRN1, FLJ21334, RNF61
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by protein A chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MKRN1.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  MKRN1 antibody can be used for detection of MKRN1 by ELISA at 1:312500. MKRN1 antibody can be used for detection of MKRN1 by western blot at 1.25 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store MKRN1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human, Mouse, Rat, Dog
• Omim nr
  223468620
• Ncbi nr
  NP_038474
• KDa
  16 kDa, 17 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  23608
• GENE symbol
  MKRN1
• Antigene name
  makorin ring finger protein 1
• Source
  Homo sapiens
• Protein nr
  Q9UHC7
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MKRN1  
• Gene symbol
  MKRN1
• Short name
  anti-MKRN1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMKRN1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7112
• Gene
  MKRN1
• Long gene name
  makorin ring finger protein 1
• Synonyms
  • RNF61
• GenBank acession
  • AF192784
• Locus
  7q34
• Discovery year
  1999-10-19
• Entrez gene record
  23608
• Pubmed identfication
  • 10843807
• RefSeq identity
  • NM_013446
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000157412

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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