anti-MAP4K4 Antibody

• Catalog number
  49-584
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.
• Gene names
  MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4
• Antibodie s label
  unlabelled serum
• Purity
  Purified
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Peptide corresponding to amino acids 931 to 947 of human NIK.
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  MAP4K4 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 ug/mL, and immunofluorescence starting at 10 ug/mL.
• Suspention pH azide
  PBS, 0.02% sodium azide.
• Keep at
  Store MAP4K4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  29427585
• Ncbi nr
  O95819
• Vial with antibody
  in solution
• NCBI GENE nr
  9448
• GENE symbol
  MAP4K4
• Antigene name
  mitogen-activated protein kinase kinase kinase kinase 4
• Source
  Homo sapiens
• Protein nr
  O95819
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MAP4K4  
• Gene symbol
  MAP4K4
• Short name
  anti-MAP4K4 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody tomitogen-activated protein kinase kinase kinase kinase 4 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  mitogen-activated protein kinase kinase kinase kinase 4, FLH21957 and HEL-S-31 and HGK and MEKKK4 and NIK, MAP4K4 and IDBG-63853 and ENSG00000071054 and 9448, transferase activity, Cytoplasm, Map4k4 and IDBG-147835 and ENSMUSG00000026074 and 26921, MAP4K4 and IDBG-630617 and ENSBTAG00000013023 and

Gene info

• Identity
  HGNC:6866
• Gene
  MAP4K4
• Long gene name
  mitogen-activated protein kinase kinase kinase kinase 4
• Synonyms
  • HGK
  • NIK
  • FLH21957
• Synonyms name
  • HPK/GCK-like kinase
  • hepatocyte progenitor kinase-like/germinal center kinase-like kinase
• GenBank acession
  • AF096300
• Locus
  2q11.2
• Discovery year
  1999-09-07
• Entrez gene record
  9448
• Pubmed identfication
  • 9890973
  • 9734811
  • 9135144
• RefSeq identity
  • NM_004834
• Classification
  • Mitogen-activated protein kinase kinase kinase kinases
• VEGA ID
  OTTHUMG00000155394

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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