anti-MALT1 Antibody

• Catalog number
  49-302
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB. MALT1 is thought to play an importantrole in NF-kappaB signaling by enchancing NF-kappaB activation through interaction with Bcl10 (Ho et al., 2005). Interaction between MALT1 and Bcl10 mediates IKK activation in vitro through facilitatiing the ubiquitination of NEMO by the ubiquitin-conjugating enzyme UBC13. Four recurrent chromosomal translocations have been described in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid issue (MALT) type. Two of them,t(14;18)(q32;q21) and t(11;18)(q21;q21), are found in 30% to 50% of extranodal MALT lymphomas. The first translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in the deregulation of MALT1 expression, whereas the second translocation generates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1). The other two much rarer translocations, t(1;14)(p22;q32)and t(1;2)(p22;p12), target Bcl10 gene on the short arm of chromosome 1. Translocations involving Bcl10 and MALT1 may lead to elevated NF-kappaB activity in MALT B-cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT1 gene. Human MALT1 isoform a is an amino acid protein of 824 amino acids, and human MALT1 isoform b is an amino acid protein of 813 amino acids.
• Gene names
  MALT1, Caspase-like protein, MLT, MLT1, Paracaspase, MALT associated translocation
• Antibodie s label
  unlabelled serum
• Purity
  Protein G Column
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  MALT1 antibody was made against amino acids 43 - 57 of MALT1 (Human).
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  MALT1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  PBS, 0.2% gelatin, 0.05% sodium azide.
• Keep at
  MALT1 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  20455075
• Ncbi nr
  Q9UDY8
• Vial with antibody
  in solution
• NCBI GENE nr
  10892
• GENE symbol
  MALT1
• Antigene name
  mucosa associated lymphoid tissue lymphoma translocation gene 1
• Source
  Homo sapiens
• Protein nr
  Q9UDY8
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MALT1  
• Gene symbol
  MALT1-AS1, MALT1
• Short name
  anti-MALT1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMALT1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  mucosa associated lymphoid tissue lymphoma translocation gene 1, IMD12 and MLT and MLT1, MALT1 and IDBG-3930 and ENSG00000172175 and 10892, protein self-association, nuclei, Malt1 and IDBG-154592 and ENSMUSG00000032688 and 240354, MALT1 and IDBG-644866 and ENSBTAG00000027916 and 504994

Gene info

• Identity
  HGNC:55306
• Gene
  MALT1-AS1
• Long gene name
  MALT1 antisense RNA 1
• Locus
  18q21.32
• Discovery year
  2020-10-16
• Entrez gene record
  101927322
• RefSeq identity
  • NR_164150
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6819
• Gene
  MALT1
• Long gene name
  MALT1 paracaspase
• Synonyms gene
  • MLT
• Synonyms gene name
  • mucosa associated lymphoid tissue lymphoma translocation gene 1
• Synonyms
  • PCASP1
• Synonyms name
  • MALT1 protease
  • paracaspase 1
• Locus
  18q21.32
• Discovery year
  1999-08-02
• Entrez gene record
  10892
• Pubmed identfication
  • 10339464
  • 10406266
  • 10523859
  • 11090634
  • 26377317
• RefSeq identity
  • NM_006785
• Classification
  • Immunoglobulin like domain containing
  • CBM complex
• VEGA ID
  OTTHUMG00000132761
• Locus Specific Databases
  • LRG_1221

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products