anti-IRAK2 Antibody

• Catalog number
  3597
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  IRAK2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.
• Gene names
  IRAK2 Antibody: IRAK-2, AI649099, 6330415L08Rik, Interleukin-1 receptor-associated kinase-like 2, IRAK-2
• Antibodie s label
  unlabelled serum
• Purity
  IRAK2 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  Anti-IRAK2 has no cross response to IRAK.
• Antigen
  RAK2 antibody was made against a peptide corresponding to 16 amino acids near the carboxy terminus of mouse IRAK2a which is common to all four isoforms.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  IRAK2 antibody can be used for detection of mouse IRAK2 by Western blot at 0.5 - 2 ug/mL.
• Suspention pH azide
  IRAK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  IRAK2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Mouse
• Omim nr
  37725373
• Ncbi nr
  AAO24761
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  108960
• GENE symbol
  Irak2
• Antigene name
  interleukin-1 receptor-associated kinase 2
• Source
  Mus musculus
• Protein nr
  Q8CFA1
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  IRAK2  
• Gene symbol
  IRAK2
• Short name
  anti-IRAK2 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toIRAK2 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  interleukin-1 receptor-associated kinase 2, IRAK-2, IRAK2 and IDBG-17914 and ENSG00000134070 and 3656, transferase activity, Plasma membranes, Irak2 and IDBG-178161 and ENSMUSG00000060477 and 108960, IRAK2 and IDBG-644615 and ENSBTAG00000006193 and 515034

Gene info

• Identity
  HGNC:6113
• Gene
  IRAK2
• Long gene name
  interleukin 1 receptor associated kinase 2
• GenBank acession
  • AF026273
• Locus
  3p25.3
• Discovery year
  1998-06-22
• Entrez gene record
  3656
• Pubmed identfication
  • 9374458
• VEGA ID
  OTTHUMG00000155358

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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