anti-Histone Deacetylase 3 Antibody
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Catalog number
49-281
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Price
Please ask
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Size
0.05 mg
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Gene info
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
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Gene names
HDAC3, RPD3, SMAP45, HD3, Histone deacetylase 3, RPD3-2
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Antibodie s label
unlabelled serum
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Purity
Protein G Column
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
Histone Deacetylase 3 antibody was made against amino acids 2 - 17 of Histone Deacetylase 3 (Human).
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Immuno application
Western Blot, immuno-histo-chemistry, immuno precipitation
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Antibody advice
Histone Deacetylase 3 antibody can be used in immunohistochemistry starting at 10 ug/mL.
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Suspention pH azide
PBS, 0.2% gelatin, 0.05% sodium azide.
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Keep at
Histone Deacetylase 3 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human
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Omim nr
3334210
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Ncbi nr
O15379
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Vial with antibody
in solution
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NCBI GENE nr
8841
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GENE symbol
HDAC3
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Antigene name
histone deacetylase 3
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Source
Homo sapiens
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Protein nr
O15379
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
HDAC3
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Short name
anti-Histone Deacetylase 3 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toHistone Deacetylase 3 (antibody to-)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year
1999-01-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NCoR/SMRT transcriptional repression complex subunits
- Histone deacetylases, class I
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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