anti-GNAS Antibody

• Catalog number
  25-797
• Price
  Please ask
• Size
  50 ug

• Gene info
  Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
• Gene names
  GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3, NESP, PHP1C
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by peptide affinity chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GNAS.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  GNAS antibody can be used for detection of GNAS by ELISA at 1:62500. GNAS antibody can be used for detection of GNAS by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store GNAS antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human, Mouse, Rat, Dog
• Omim nr
  4504047
• Ncbi nr
  NP_000507
• KDa
  46 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  2778
• GENE symbol
  GNAS
• Antigene name
  GNAS complex locus
• Source
  Homo sapiens
• Protein nr
  P63092
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  GNAS  
• Gene symbol
  GNAS-AS1, GNAS
• Short name
  anti-GNAS Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toGNAS (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24872
• Gene
  GNAS-AS1
• Long gene name
  GNAS antisense RNA 1
• Synonyms gene
  • GNASAS
  • GNAS-AS
• Synonyms gene name
  • GNAS antisense RNA (non-protein coding)
  • GNAS antisense RNA 1 (non-protein coding)
• Synonyms
  • SANG
  • NESP-AS
  • NESPAS
  • GNAS1AS
  • NCRNA00075
• Synonyms name
  • GNAS antisense
  • non-protein coding RNA 75
• GenBank acession
  • AJ251759
• Locus
  20q13.32
• Discovery year
  2008-06-20
• Entrez gene record
  149775
• Pubmed identfication
  • 10749992
• RefSeq identity
  • NR_002785
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000060481
• Locus Specific Databases
  • LRG_1051

Gene info

• Identity
  HGNC:4392
• Gene
  GNAS
• Long gene name
  GNAS complex locus
• Synonyms gene
  • GNAS1
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
• Synonyms
  • NESP55
  • NESP
  • GNASXL
  • GPSA
  • SCG6
  • SgVI
• Synonyms name
  • secretogranin VI
  • G protein subunit alpha S
• GenBank acession
  • M21142
• Locus
  20q13.32
• Discovery year
  1990-06-29
• Entrez gene record
  2778
• RefSeq identity
  • NM_000516
• Classification
  • G protein subunits alpha, group s
  • Granins
• VEGA ID
  OTTHUMG00000033069
• Locus Specific Databases
  • LOVD - Leiden Open Variation Database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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