anti-FLASH Antibody

• Catalog number
  2271
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  FLASH Antibody: A novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. FLASH is widely expressed.
• Gene names
  FLASH Antibody: CED-4, FLASH, RIP25, KIAA1315, CASP8-associated protein 2, FLICE-associated huge protein
• Antibodie s label
  unlabelled serum
• Purity
  FLASH Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  FLASH antibody was made against a synthetic peptide corresponding to amino acids near the carboxy terminus of human FLASH which differ from those of mouse by one amino acid.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  FLASH antibody can be used for detection of FLASH by Western blot at 0.5 ug/mL. An approximate 220 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 10 ug/mL.
• Suspention pH azide
  FLASH Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  FLASH antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  5533376
• Ncbi nr
  AF165161
• KDa
  220 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  9994
• GENE symbol
  CASP8AP2
• Antigene name
  caspase 8 associated protein 2
• Source
  Homo sapiens
• Protein nr
  Q9UKL3
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FLASH  
• Gene symbol
  CASP8AP2
• Short name
  anti-FLASH Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toFLASH (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1510
• Gene
  CASP8AP2
• Long gene name
  caspase 8 associated protein 2
• Synonyms gene name
  • CASP8 associated protein 2
• Synonyms
  • FLASH
  • CED-4
  • RIP25
  • FLJ11208
  • KIAA1315
• Synonyms name
  • FLICE-associated huge protein
• GenBank acession
  • AB037736
• Locus
  6q15
• Discovery year
  1999-12-10
• Entrez gene record
  9994
• Pubmed identfication
  • 10235259
  • 17245429
  • 17003126
• RefSeq identity
  • NM_001137667
• VEGA ID
  OTTHUMG00000015212

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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