anti-CRBN Antibody

• Catalog number
  8115
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  CRBN, a member of the Lon protease protein family, plays a role in brain development (1). It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8 (2). CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain (3,4).
• Gene names
  Cereblon, AD-006, DKFZp781K0715, MGC27358, MRT2A
• Antibodie s label
  unlabelled serum
• Purity
  CRBN antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms.
• Antigen
  CRBN antibody was made against a 16 amino acid peptide near the carboxy terminus of human CRBN.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  CRBN antibody can be used for detection of CRBN by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  CRBN antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  CRBN antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  39545580
• Ncbi nr
  NP_057386
• KDa
  Predicted: 49 kDa Observed: 54 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  51185
• GENE symbol
  CRBN
• Antigene name
  cereblon
• Source
  homo sapiens
• Protein nr
  Q96SW2
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CRBN  
• Gene symbol
  CRBN
• Short name
  anti-CRBN Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCRBN (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:30185
• Gene
  CRBN
• Long gene name
  cereblon
• Synonyms gene
  • MRT2A
• Synonyms gene name
  • mental retardation, non-syndromic, autosomal recessive, 2A
• Synonyms
  • MRT2
• GenBank acession
  • BC017419
• Locus
  3p26.2
• Discovery year
  2004-05-19
• Entrez gene record
  51185
• Pubmed identfication
  • 15557513
• RefSeq identity
  • NM_016302
• VEGA ID
  OTTHUMG00000090261

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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