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Gene info
CKIP1 Antibody: CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
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Gene names
CKIP1 Antibody: OC120, CKIP-1, CKIP1, OC120, HQ0024c, Pleckstrin homology domain-containing family O member 1, C-Jun-binding protein, PH domain-containing family O member 1
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Antibodie s label
unlabelled serum
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Purity
CKIP1 Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
CKIP1 antibody was made against an 18 amino acid synthetic peptide from near the carboxy terminus of human CKIP1.
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Immuno application
ELISA, Western Blot
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Antibody advice
CKIP1 antibody can be used for detection of CKIP1 by Western blot at 1 - 2 ug/mL.
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Suspention pH azide
CKIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
CKIP1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human, Mouse, Rat
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Omim nr
20149626
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Ncbi nr
NP_057358
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
51177
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GENE symbol
PLEKHO1
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Antigene name
pleckstrin homology domain containing, family O member 1
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Source
Homo sapiens
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Protein nr
Q53GL0
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
