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Gene info
CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.
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Gene names
CDKN1C Antibody: BWS, WBS, p57, BWCR, KIP2, p57Kip2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57
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Antibodie s label
unlabelled serum
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Purity
CDKN1C Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Spicific to
At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kDa in SDS-PAGE. CDKN1C antibody is predicted to not cross react with other CIP/KIP proteins.
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Antigen
CDKN1C antibody was made against a 17 amino acid synthetic peptide near the amino terminus of human CDKN1C.
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Immuno application
ELISA, Western Blot, immuno fluorescence
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Antibody advice
CDKN1C antibody can be used for detection of CDKN1C by Western blot at 1 - 2 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azide
CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
CDKN1C antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human
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Omim nr
4557441
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Ncbi nr
NP_000067
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KDa
35 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
1028
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GENE symbol
CDKN1C
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Antigene name
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
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Source
homo sapiens
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Protein nr
P49918
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CDKN1C
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Short name
anti-CDKN1C Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody tocyclin-dependent phosphorylation catalyst inhibitor 1C (p57, Kip2) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
cyclin-dependent kinase inhibitor 1C (p57, Kip2), BWCR and BWS and KIP2 and p57 and p57Kip2 and WBS, CDKN1C and IDBG-23324 and ENSG00000129757 and 1028, protein binding, nuclei, Cdkn1c and IDBG-212725 and ENSMUSG00000037664 and 12577, CDKN1C and IDBG-645186 and ENSBTAG00000031184 and 510972
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