anti-BIRC7 Antibody [88C570]
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Catalog number
49-265
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Price
Please ask
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Size
0.05 mg
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Gene info
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, Kasof and Gomes , Vucic et al. and Ashhab et al. have identified a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-a and Livin-b. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
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Gene names
BIRC7, KIAP, Livin inhibitor of apoptosis, MLIAP, ML-IAP, RNF50, RING finger protein 50, LIVIN
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Antibodie s label
unlabelled serum
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Purity
Protein G Column
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
[88C570]
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Immunoglobulin
IgG1
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Antigen
BIRC7 monoclonal antibody was made against a fusion protein of BIRC7 (Human).
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Immuno application
Western Blot, immuno-histo-chemistry
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Antibody advice
BIRC7 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 ug/mL, and immunofluorescence starting at 10 ug/mL.
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Suspention pH azide
PBS containing 0.05% BSA and 0.05% sodium azide
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Keep at
BIRC7 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human
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Omim nr
21759008
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Ncbi nr
Q96CA5
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Vial with antibody
in solution
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NCBI GENE nr
79444
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GENE symbol
BIRC7
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Antigene name
baculoviral IAP repeat containing 7
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Source
Homo sapiens
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Protein nr
Q96CA5
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
BIRC7
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Short name
anti-BIRC7 Antibody [88C570]
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toBIRC7 (antibody to-) [88C570]
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Alternative technique
antibodies
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Alternative to gene target
baculoviral IAP repeat containing 7, BIRC7 and IDBG-85846 and ENSG00000101197 and 79444, enzyme binding, nuclei, Birc7 and IDBG-213920 and ENSMUSG00000038840 and 329581, BIRC7 and IDBG-640704 and ENSBTAG00000004911 and 514508
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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