anti-BIRC2 Antibody

• Catalog number
  49-264
• Price
  Please ask
• Size
  0.05 mL

• Gene info
  The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. c-IAP1 and c-IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) family originally identified in baculoviruses. Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-a by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
• Gene names
  BIRC2, API1, C-IAP1, CIAP1, Hiap-2, IAP homolog B, HIAP2, IAP-2, RNF48, Apoptosis inhibitor 1, IAP2, MIHB, RING finger protein 48
• Antibodie s label
  unlabelled serum
• Purity
  Antisera
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  BIRC2 antibody was made against a synthetic peptide corresponding to 361 - 372 of BIRC2 (Human).
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  BIRC2 antibody can be used in immunohistochemistry starting at 10 ug/mL.
• Suspention pH azide
  Neat serum, 0.05% sodium azide.
• Keep at
  BIRC2 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  2497238
• Ncbi nr
  Q13490
• Vial with antibody
  in solution
• NCBI GENE nr
  329
• GENE symbol
  BIRC2
• Antigene name
  baculoviral IAP repeat containing 2
• Source
  Homo sapiens
• Protein nr
  Q13490
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BIRC2  
• Gene symbol
  BIRC2
• Short name
  anti-BIRC2 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toBIRC2 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  baculoviral IAP repeat containing 2, API1 and c-IAP1 and cIAP1 and Hiap-2 and HIAP2 and MIHB and RNF48, BIRC2 and IDBG-69075 and ENSG00000110330 and 329, protein N-terminus binding, nuclei, Birc2 and IDBG-133125 and ENSMUSG00000057367 and 11797, BIRC2 and IDBG-629142 and ENSBTAG00000035735 and 539314

Gene info

• Identity
  HGNC:590
• Gene
  BIRC2
• Long gene name
  baculoviral IAP repeat containing 2
• Synonyms gene
  • API1
• Synonyms gene name
  • baculoviral IAP repeat-containing 2
• Synonyms
  • cIAP1
  • hiap-2
  • MIHB
  • RNF48
  • c-IAP1
• Synonyms name
  • NFR2-TRAF signalling complex protein
  • apoptosis inhibitor 1
• GenBank acession
  • L49431
• Locus
  11q22.2
• Discovery year
  1998-06-10
• Entrez gene record
  329
• Pubmed identfication
  • 8552191
  • 8548810
• RefSeq identity
  • NM_001166
• Classification
  • Baculoviral IAP repeat containing
  • Ring finger proteins
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000167325

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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